Article

Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load

2020-04-18

Abstract excerpt

The amyloid precursor protein (APP) is a type I transmembrane protein with unknown physiological function but potential impact in neurodegeneration. The current study demonstrates that APP signals to the nucleus causing the generation of aggregates comprising its adapter protein FE65 and the tumour suppressor proteins p53 and PML. The PML nuclear body generation, known to be of relevance in virus defence and cell...

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Identifiers and source

Literature Corpus work: 9625c6e0-e7cf-5272-a7ad-2695e8f8ea6f
DOI: 10.1101/2020.04.16.001255

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