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Extracellular disposal of nuclear waste by APP: a protective mechanism impaired in Alzheimer’s disease

2024-02-12

Abstract excerpt

Although the amyloid beta (Aβ) hypothesis 1 has long been central to Alzheimer’s disease (AD) research, effective therapeutic strategies remain elusive 2,3 . Here we re-evaluate the functions of amyloid precursor protein (APP) and reveal its critical function in protecting against nuclear impairment-induced cell death and inflammation 4,5 . Overexpression of APP mitigated etoposide or lamin A knockdown-induced...

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Literature Corpus work
3c94c700-ea3c-54f7-a3e2-addfa87c7d4c
DOI
10.1101/2024.02.10.579739
Open publication

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Extracellular disposal of nuclear waste by APP: a protective mechanism impaired in Alzheimer’s diseaseDOI 10.1101/2024.02.10.579739
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