Article
Glaucoma Genetic Risk Scores in the Million Veteran Program.
Ophthalmology - 1 Nov 2022
Waksmunski Andrea R, Kinzy Tyler G, Cruz Lauren A, Nealon Cari L, Halladay Christopher W, Simpson Piana, Canania Rachael L, Anthony Scott A, Roncone David P, Sawicki Rogers Lea, Leber Jenna N, Dougherty Jacquelyn M, Greenberg Paul B, Sullivan Jack M, Wu Wen-Chih, Iyengar Sudha K, Crawford Dana C, Peachey Neal S, Cooke Bailey Jessica N
Abstract excerpt
PURPOSE: Primary open-angle glaucoma (POAG) is a degenerative eye disease for which early treatment is critical to mitigate visual impairment and irreversible blindness. POAG-associated loci individually confer incremental risk. Genetic risk score(s) (GRS) could enable POAG risk stratification. Despite significantly higher POAG burden among individuals of African ancestry (AFR), GRS are limited in this...
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