Article

DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions

2022-11-03

Abstract excerpt

We report an Osprey-based computational protocol to prospectively identify oncogenic mutations that act via disruption of molecular interactions. It is applicable to analyze both protein-protein and protein-DNA interfaces and has been validated on a dataset of clinically relevant mutations. In addition, it was used to predict previously uncharacterized patient mutations in CDK6 and p16 genes, which were experiment...

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Literature Corpus work: f7234331-c429-5152-9e9c-9b829e21579f
DOI: 10.1101/2022.11.02.514903

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