Article

A patient-centric knowledge graph approach to prioritize mutants for selective anti-cancer targeting

2024-10-01

Abstract excerpt

Personalized oncology has revolutionized cancer treatment by targeting specific genetic aberrations in tumors. However, the identification of suitable targets for anti-cancer therapies remains a challenge. In this study, we introduce a knowledge graph approach to prioritize cancer mutations with clinical, functional, and structural significance as potential therapeutic targets. Focusing on the human kinome, we int...

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Literature Corpus work: f1379d5f-c340-5daf-9cf1-d26de773694c
DOI: 10.1101/2024.09.29.615658

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