Article
e-MutPath: computational modeling reveals the functional landscape of genetic mutations rewiring interactome networks.
Nucleic acids research - 11 Jan 2021
Li Yongsheng, Burgman Brandon, Khatri Ishaani S, Pentaparthi Sairahul R, Su Zhe, McGrail Daniel J, Li Yang, Wu Erxi, Eckhardt S Gail, Sahni Nidhi, Yi S Stephen
Abstract excerpt
Understanding the functional impact of cancer somatic mutations represents a critical knowledge gap for implementing precision oncology. It has been increasingly appreciated that the interaction profile mediated by a genomic mutation provides a fundamental link between genotype and phenotype. However, specific effects on biological signaling networks for the majority of mutations are largely unknown by...
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