Article

A blueprint for mutation-defined hallmark vulnerabilities across human cancers

2025-10-25

Abstract excerpt

Hallmark gene mutations shape cancer cell vulnerabilities and inform drug discovery 1–3 . A systematic map of hallmark gene mutation-defined cancer dependencies and therapeutic responses is essential to uncover novel targets and refine therapeutic strategies. Here, we present the first pan-cancer blueprint of hallmark vulnerabilities, systematically linking hallmark gene mutation markers to cancer cell dependenci...

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Literature Corpus work: 877b8312-c093-5b17-a732-bdd853353fa8
DOI: 10.1101/2025.10.24.684315

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