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Article

Detection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry.

Scientific reports - 6 Nov 2024

Shahi Mahdiyeh, Pringle Steven, Morris Michael, Garcia Diogo Moniz, Quiñones-Hinojosa Alfredo, Cooks R Graham

Abstract excerpt

Desorption electrospray ionization (DESI) tandem mass spectrometry (MS) is used to assess mutation status of isocitrate dehydrogenase (IDH) in human gliomas. Due to the diffuse nature of gliomas, total gross resection is not normally achieved during surgery, leading to tumor recurrence. The mutation status of IDH has clinical significance due to better prognosis in IDH-mutant patients. The mutant IDH converts...

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Identifiers

PMID: 39500924
DOI: 10.1038/s41598-024-77044-y
PMCID: PMC11538546

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