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Article

Intraoperative detection of isocitrate dehydrogenase mutations in human gliomas using a miniature mass spectrometer.

Analytical and bioanalytical chemistry - 1 Dec 2019

Brown Hannah Marie, Pu Fan, Dey Mahua, Miller James, Shah Mitesh V, Shapiro Scott A, Ouyang Zheng, Cohen-Gadol Aaron A, Cooks R Graham

Abstract excerpt

Knowledge of the isocitrate dehydrogenase (IDH) mutation status of glioma patients could provide insights for decision-making during brain surgery. However, pathology is not able to provide such information intraoperatively. Here we describe the first application of a miniature mass spectrometer (MS) to the determination of IDH mutation status in gliomas intraoperatively. The instrumentation was modified to be...

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Biopsy
Brain Neoplasms
Cohort Studies
Glioma
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spectrometry, Mass, Electrospray Ionization

Tandem Mass Spectrometry

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Identifiers

PMID: 31754769
DOI: 10.1007/s00216-019-02198-y
PMCID: PMC8396075

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