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Article

Tissue 2-Hydroxyglutarate and Preoperative Seizures in Patients With Diffuse Gliomas.

Neurology - 23 Nov 2021

Ohno Makoto, Hayashi Yoshiharu, Aikawa Hiroaki, Hayashi Mitsuhiro, Miyakita Yasuji, Takahashi Masamichi, Matsushita Yuko, Yoshida Akihiko, Satomi Kaishi, Ichimura Koichi, Hamada Akinobu, Narita Yoshitaka

Abstract excerpt

BACKGROUND AND OBJECTIVES: Mutant isocitrate dehydrogenase (IDH) 1/2 gene products gain a new ability to produce D-2-hydroxyglutarate (D2HG). IDH1/2 mutations are thought to be associated with seizures owing to the structural similarity between D2HG and glutamate. However, the effects of D2HG on seizures in clinical settings are not fully understood. We sought to investigate the relationship between tissue...

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Identifiers

PMID: 34610989
DOI: 10.1212/WNL.0000000000012893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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