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Isocitrate Dehydrogenase Mutation Assessment in Human Glioma Using Desorption Electrospray Ionization-Multiple Reaction Monitoring.

Analytical chemistry - 4 Aug 2026

Shahi Mahdiyeh, Garcia Diogo Moniz, Quiñones-Hinojosa Alfredo, Cooks R Graham

Abstract excerpt

The mutation status of isocitrate dehydrogenase (IDH) in glioma patients has diagnostic and prognostic significance but is available only after surgery. Rapid and sensitive intraoperative molecular diagnosis is essential for distinguishing tumor from infiltrative and from normal brain tissue to maximize safe resection. IDH-mutant (mut)tumors produce high concentrations of 2-hydroxyglutarate (2HG), which serves as...

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Brain Neoplasms
Glioma
Glutarates
Isocitrate Dehydrogenase
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spectrometry, Mass, Electrospray Ionization

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PMID: 42477897
DOI: 10.1021/acs.analchem.6c00520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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