Article
Rapid detection of IDH mutations in gliomas by intraoperative mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jun 2024
Hua Wei, Zhang Wenpeng, Brown Hannah, Wu Junhan, Fang Xinqi, Shahi Mahdiyeh, Chen Rong, Zhang Haoyue, Jiao Bin, Wang Nan, Xu Hao, Fu Minjie, Wang Xiaowen, Zhang Jinsen, Zhang Xin, Wang Qijun, Zhu Wei, Ye Dan, Garcia Diogo Moniz, Chaichana Kaisorn, Cooks R Graham, Ouyang Zheng, Mao Ying, Quinones-Hinojosa Alfredo
Abstract excerpt
The development and performance of two mass spectrometry (MS) workflows for the intraoperative diagnosis of isocitrate dehydrogenase (IDH) mutations in glioma is implemented by independent teams at Mayo Clinic, Jacksonville, and Huashan Hospital, Shanghai. The infiltrative nature of gliomas makes rapid diagnosis necessary to guide the extent of surgical resection of central nervous system (CNS) tumors. The...
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