Article
Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma.
International journal of cancer - 15 Dec 2021
Lan Chunyan, Li Hainan, Wang Lei, Zhang Jing, Wang Xiaodong, Zhang Rumeng, Yuan Xiaoai, Wu Taihua, Wu Jie, Lu Ming, Ma Xu
Abstract excerpt
Isocitrate dehydrogenase (IDH) gene mutations are important predictive molecular markers to guide surgical strategy in brain cancer therapy. Herein, we presented a method using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for absolute quantification of 2-hydroxyglutarate (2-HG) on tissues to identify IDH mutations and evaluate tumor residue. This analytical method was tested...
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