Article
Rapid detection of mutation in isocitrate dehydrogenase 1 and 2 genes using mass spectrometry.
Brain tumor pathology - 1 Apr 2018
Kanamori Masayuki, Maekawa Masamitsu, Shibahara Ichiyo, Saito Ryuta, Chonan Masashi, Shimada Miki, Sonoda Yukihiko, Kumabe Toshihiro, Watanabe Mika, Mano Nariyasu, Tominaga Teiji
Abstract excerpt
The 2016 World Health Organization classification of tumors of the central nervous system was recently revised. Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes and chromosome 1p/19q codeletion are especially important for both the integrated diagnosis and the determination of surgical strategy. To establish a method for intraoperative molecular diagnosis, a simple, rapid method was developed for...
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