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Article

Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2016

Kalinina Juliya, Ahn Jun, Devi Narra S, Wang Liya, Li Yuancheng, Olson Jeffrey J, Glantz Michael, Smith Thomas, Kim Ella L, Giese Alf, Jensen Randy L, Chen Clark C, Carter Bob S, Mao Hui, He Miao, Van Meir Erwin G

Abstract excerpt

PURPOSE: Elevation in D-2-Hydroxyglutarate (D-2HG) has recently emerged as a mandatory byproduct of mutated Isocitrate Dehydrogenase (IDH) genes 1 and 2 in glioma patients. The goal of the present study was to demonstrate the feasibility of detection of elevated levels of D-2HG in the cerebrospinal fluid (CSF) of glioma patients that carry point substitutions in the IDH gene. EXPERIMENTAL DESIGN: We developed a...

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Identifiers

PMID: 27340277
DOI: 10.1158/1078-0432.CCR-15-2965
PMCID: PMC5443654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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