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Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy

9 Oct 2024

Abstract excerpt

Immune checkpoint inhibitors interfere with T cell exhaustion but often fail to cure or control cancer long-term in patients. Using a genetic screen in C57BL/6J mice, we discovered a mutation in host H2-Aa that caused strong immune-mediated resistance to mouse melanomas. H2-Aa encodes an MHC class II α chain, and its absence in C57BL/6J mice eliminates all MHC-II expression. H2-Aa deficiency, specifically in...

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PMID: 39470607
DOI: 10.1084/jem.20240797

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