Article

IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas

2024-09-02

Abstract excerpt

<title>Abstract</title> Background In order for cancers to progress, they must evade elimination by CD8 T cells or other immune mechanisms. CD8 T cells recognize and kill tumor cells that display immunogenic tumor peptides bound to MHC I molecules. One of the ways that cancers can escape such killing is by reducing expression of MHC I molecules, and loss of MHC I is frequently observed in tumors. There are mu...

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Literature Corpus work: 4554e15a-4643-5417-8dcc-0b9747103c81
DOI: 10.21203/rs.3.rs-4997954/v1

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