Article

<i>Setdb1</i> -loss induces type-I interferons and immune clearance of melanoma

2023-05-24

Abstract excerpt

<h4>Summary</h4> Despite recent advances in the treatment of melanoma, many patients with metastatic disease still succumb to their disease. To identify tumor-intrinsic modulators of immunity to melanoma, we performed a whole-genome CRISPR screen in melanoma and identified multiple components of the HUSH complex, including Setdb1 , as hits. We found that loss of Setdb1 leads to increased immunogenicity and comp...

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Literature Corpus work: 86e0d2c8-60d5-5723-a05b-abc6807bcd5a
DOI: 10.1101/2023.05.23.541922

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