Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.

doi:10.1038/ncomms15440

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Article

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.

Nature communications - 31 May 2017

Sucker Antje, Zhao Fang, Pieper Natalia, Heeke Christina, Maltaner Raffaela, Stadtler Nadine, Real Birgit, Bielefeld Nicola, Howe Sebastian, Weide Benjamin, Gutzmer Ralf, Utikal Jochen, Loquai Carmen, Gogas Helen, Klein-Hitpass Ludger, Zeschnigk Michael, Westendorf Astrid M, Trilling Mirko, Horn Susanne, Schilling Bastian, Schadendorf Dirk, Griewank Klaus G, Paschen Annette

Abstract excerpt

Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. Our study demonstrates a genetic evolution of IFNγ resistance in different melanoma patient models. Chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade,...

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PMID: 28561041
DOI: 10.1038/ncomms15440
PMCID: PMC5460020

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JAK1
JAK2

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