Article
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.
Nature - 1 May 2022
Oliveira Giacomo, Stromhaug Kari, Cieri Nicoletta, Iorgulescu J Bryan, Klaeger Susan, Wolff Jacquelyn O, Rachimi Suzanna, Chea Vipheaviny, Krause Kate, Freeman Samuel S, Zhang Wandi, Li Shuqiang, Braun David A, Neuberg Donna, Carr Steven A, Livak Kenneth J, Frederick Dennie T, Fritsch Edward F, Wind-Rotolo Megan, Hacohen Nir, Sade-Feldman Moshe, Yoon Charles H, Keskin Derin B, Ott Patrick A, Rodig Scott J, Boland Genevieve M, Wu Catherine J
Abstract excerpt
Within the tumour microenvironment, CD4+ T cells can promote or suppress antitumour responses through the recognition of antigens presented by human leukocyte antigen (HLA) class II molecules1,2, but how cancers co-opt these physiologic processes to achieve immune evasion remains incompletely understood. Here we performed in-depth analysis of the phenotype and tumour specificity of CD4+ T cells infiltrating human...
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