Article
Antigen presentation and T cell development in H2-M-deficient mice.
Science (New York, N.Y.) - 1 Mar 1996
Fung-Leung W P, Surh C D, Liljedahl M, Pang J, Leturcq D, Peterson P A, Webb S R, Karlsson L
Abstract excerpt
HLA-DM (DM) facilitates peptide loading of major histocompatibility complex class II molecules in human cell lines. Mice lacking functional H2-M, the mouse equivalent of DM, have normal amounts of class II molecules at the cell surface, but most of these are associated with invariant chain-derived CLIP peptides. These mice contain large numbers of CD4+ T cells, which is indicative of positive selection in the...
Topics
- Animals
- Antigen Presentation
- Antigen-Presenting Cells
- Antigens, Differentiation, B-Lymphocyte
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Gene Targeting
- Histocompatibility Antigens Class II
- Isoantigens
- Lymphocyte Activation
- Mice
- Molecular Sequence Data
- Mutation