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Article

Antigen presentation and T cell development in H2-M-deficient mice.

Science (New York, N.Y.) - 1 Mar 1996

Fung-Leung W P, Surh C D, Liljedahl M, Pang J, Leturcq D, Peterson P A, Webb S R, Karlsson L

Abstract excerpt

HLA-DM (DM) facilitates peptide loading of major histocompatibility complex class II molecules in human cell lines. Mice lacking functional H2-M, the mouse equivalent of DM, have normal amounts of class II molecules at the cell surface, but most of these are associated with invariant chain-derived CLIP peptides. These mice contain large numbers of CD4+ T cells, which is indicative of positive selection in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8638109
DOI: 10.1126/science.271.5253.1278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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