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Article

Metastatic melanoma cells evade immune detection by silencing STAT1.

International journal of molecular sciences - 17 Feb 2015

Osborn JoDi Lynn, Greer Susanna F

Abstract excerpt

Transcriptional activation of major histocompatibility complex (MHC) I and II molecules by the cytokine, interferon γ (IFN-γ), is a key step in cell-mediated immunity against pathogens and tumors. Recent evidence suggests that suppression of MHC I and II expression on multiple tumor types plays important roles in tumor immunoevasion. One such tumor is malignant melanoma, a leading cause of skin cancer-related...

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Share to Histocompatibility Antigens Class II
Share to Interferon-gamma
Share to Interferon gamma Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Regulatory Factor-1

Share to Janus Kinases

Share to Melanoma, Cutaneous Malignant

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Source

Open in PubMed Open full text

Identifiers

PMID: 25690042
DOI: 10.3390/ijms16024343
PMCID: PMC4346960

Genes

STAT1
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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