Article

Tracking antigen-specific T cell response to cancer immunotherapy

2024-12-03

Abstract excerpt

In each human or model animal, T cell receptor (TCR) of each effector/memory T cell clone recognizes from one to several cognate peptide-MHC complexes (pMHC). Limited knowledge on TCR repertoire specificities restricts our capacity to rationally interpret this information, both diagnostically and in preclinical research. Here we 1) develop cost-efficient wet lab and computational pipeline to identify mouse TCRs sp...

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Literature Corpus work: 3f221ff2-dc7a-5ed5-96be-3e2e77575d27
DOI: 10.1101/2024.11.29.626027

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