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Hippo Signaling Pathway Regulates Cancer Cell–Intrinsic MHC-II Expression

11 Oct 2022

Abstract excerpt

MHC-II is known to be mainly expressed on the surface of antigen-presenting cells. Evidence suggests MHC-II is also expressed by cancer cells and may be associated with better immunotherapy responses. However, the role and regulation of MHC-II in cancer cells remain unclear. In this study, we leveraged data mining and experimental validation to elucidate the regulation of MHC-II in cancer cells and its role in...

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PMID: 36219700
DOI: 10.1158/2326-6066.cir-22-0227

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