Article

Inhibition of UBE2N in regulatory T-cells boosts immunity against cancer

2024-10-25

Abstract excerpt

Regulatory T (Treg) cells prevent autoimmunity and facilitate cancer immune evasion. Depletion of Tregs is a promising cancer therapy, but risks of autoimmune reactions hamper its clinical translation. Here, we demonstrate that temporally induced deletion of Ube2n in Tregs (Ube2n Treg-KO ) of adult mice results in a robust expansion and activation of cytotoxic CD8 + T-cells in response to cancer cell challenges,...

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Literature Corpus work: 5ad7ad40-eab8-572e-9853-29eea309c997
DOI: 10.1101/2024.10.22.619436

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