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Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2016

Bousquet M, Noirot C, Accadbled F, Sales de Gauzy J, Castex M P, Brousset P, Gomez-Brouchet A

Abstract excerpt

BACKGROUND: Whole-genome sequencing studies have recently shown that osteosarcomas (OSs) display high rates of structural variation, i.e. they contain many somatic mutations and copy number alterations. TP53 and RB1 show recurrent somatic alterations in concordant studies, suggesting that they could be key players in bone oncogenesis. PATIENTS AND METHODS: we carried out whole-genome sequencing of DNA from seven...

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DNA Copy Number Variations
Exome
Genetic Heterogeneity
Osteosarcoma
Proto-Oncogene Proteins c-mdm2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinoblastoma Binding Proteins

Tumor Suppressor Protein p53

Ubiquitin-Protein Ligases

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PMID: 26787232
DOI: 10.1093/annonc/mdw009

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MDM2

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