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Article

CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway.

Cell genomics - 9 Oct 2024

Cao Canhui, Xu Miaochun, Wei Ye, Peng Ting, Lin Shitong, Liu Xiaojie, Xu Yashi, Chu Tian, Liu Shiyi, Wu Ping, Hu Bai, Ding Wencheng, Li Li, Ma Ding, Wu Peng

Abstract excerpt

Evidence from clinical trials suggests that CXCR4 antagonists enhance immunotherapy effectiveness in several cancers. However, the specific mechanisms through which CXCR4 contributes to immune cell phenotypes are not fully understood. Here, we employed single-cell transcriptomic analysis and identified CXCR4 as a marker gene in T cells, with CD8+PD-1high exhausted T (Tex) cells exhibiting high CXCR4 expression....

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Topics

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

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Source

Open in PubMed Open full text

Identifiers

PMID: 39317187
DOI: 10.1016/j.xgen.2024.100659
PMCID: PMC11602566

Genes

CXCR4
JAK2
STAT3
TOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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