Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CXCR4 signaling in health and disease.

Immunology letters - 1 Sept 2016

Pozzobon Tommaso, Goldoni Giacomo, Viola Antonella, Molon Barbara

Abstract excerpt

Chemokines and chemokine receptors regulate multiple processes such morphogenesis, angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out for its pleiotropic roles as well as for its involvement in several pathological conditions, including immune diseases, viral infections and cancer. For these reasons, CXCR4 represents a crucial target in drug development. In this review, we discuss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CXCL12
Share to Immunity
Share to Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Morphogenesis

Share to Neovascularization, Physiologic

Share to Primary Immunodeficiency Diseases

Share to Receptors, CXCR4

Source

Identifiers

PMID: 27363619
DOI: 10.1016/j.imlet.2016.06.006

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CXCR4 signaling in health and disease.PMID 27363619Read ↗

Aberrant CXCR4 Signaling at Crossroad of WHIM Syndrome and Waldenstrom's Macroglobulinemia.Semantic proximity Read ↗

The complex nature of CXCR4 mutations in WHIM syndrome.Semantic proximity Read ↗

Regulation of CXCR4 signalingSemantic proximity Read ↗

WHIM syndrome: A defect in CXCR4 signalingSemantic proximity Read ↗

CXCR4 mutations in WHIM syndrome: a misguided immune system?Semantic proximity Read ↗

An overall picture of chemokine receptors: basic research and drug development.Semantic proximity Read ↗

CXCL12/CXCR4-Axis Dysfunctions: Markers of the Rare Immunodeficiency Disorder WHIM SyndromeSemantic proximity Read ↗

The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4.Semantic proximity Read ↗

CXCR4: from B-cell development to B cell–mediated diseasesSemantic proximity Read ↗

CXCL12/CXCR4-axis dysfunctions: Markers of the rare immunodeficiency disorder WHIM syndrome.Semantic proximity Read ↗

Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progressionSemantic proximity Read ↗

WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.