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High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors

28 Aug 2018

Abstract excerpt

CD8+ T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions of CD8+ T cells from 53 individuals with lung cancer, we defined those subsets that are enriched in tumors compared with cancer-free tissues and blood. Besides exhausted and activated cells, we identified CXCR5+ TIM-3– CD8+ T...

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PMID: 30154266
DOI: 10.1084/jem.20180684

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