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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

24 Jan 2019

Abstract excerpt

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, metabolic dysregulation, poor memory recall and homeostatic self-renewal, and distinct transcriptional and epigenetic programs. The ability to reinvigorate Tex...

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PMID: 30676822
DOI: 10.1146/annurev-immunol-041015-055318

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