Article

Single-cell transcriptome analysis reveals TOX as a promoting factor for T-cell exhaustion and a predictor for anti-PD1 responses in human cancer

2019-05-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> T cells exhibit heterogeneous functional states in the tumor microenvironment. Immune checkpoint inhibitors (ICIs) can reinvigorate only the stem cell-like progenitor exhausted T cells, which suggests that inhibiting the exhaustion progress will improve the efficacy of immunotherapy. Thus, regulatory factors promoting T-cell exhaustion could serve as potential targets for de...

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Literature Corpus work: d03a4328-a0d2-5777-ad7a-d434042a6ac8
DOI: 10.1101/641316

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