Article

Identifying Distinct Molecular Response of CAR-T cells to Solid Tumors by Synthetic Single-Cell Transcriptomic Analyses

2025-09-18

Abstract excerpt

Chimeric Antigen Receptor (CAR)-T cell therapy is a novel personalized treatment that engineers patient immune cells to fight against cancer cells. Recently, CAR-T cell therapy has demonstrated remarkable success in the treatment of hematopoietic cancers, whereas the treatment of solid tumors is more challenging, likely in part due to their severely immunosuppressive tumor microenvironment. To address distinct mol...

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Literature Corpus work: e8968e1c-b0ff-51df-bcca-840641ceea40
DOI: 10.1101/2025.09.17.676755

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