Article

Pan-cancer mapping of single T cell profiles reveals a TCF1:CXCR6-CXCL16 regulatory axis essential for effective anti-tumor immunity

2021-10-31

Abstract excerpt

Unleashing cytotoxic CD8 + T cells for effective cancer treatment requires understanding T cell states across different tumor microenvironments. Here, we developed an algorithm to recover both shared and tumor type specific programs and used it to analyze a scRNA-seq compendium of 38,852 CD8 + T cells from 141 patients spanning nine different human cancers. We uncovered a pan-cancer T cell dysfunction program th...

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Literature Corpus work: 57c33081-8bf7-52a0-82e9-b916f6f70905
DOI: 10.1101/2021.10.31.466532

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