Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment

Abstract excerpt

Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8 + T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show that CXCL13 , highly expressed in tumor-infiltrating exhausted CD8 + T cells, induces CD4 + follicular helper T (T FH ) cell infiltration, contributing to...

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