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Characterization of Exhausted T Cell Signatures in Pan-Cancer Settings

5 Mar 2025

Abstract excerpt

T cells play diverse roles in cancer immunology, acting as tumor suppressors, cytotoxic effectors, enhancers of cytotoxic T lymphocyte responses and immune suppressors; providing memory and surveillance; modulating the tumor microenvironment (TME); or activating innate immune cells. However, cancer cells can disrupt T cell function, leading to T cell exhaustion and a weakened immune response against the tumor....

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PMID: 40076932
DOI: 10.3390/ijms26052311

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