Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.

doi:10.1016/j.molmet.2017.03.011

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Article

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.

Molecular metabolism - 1 Jun 2017

Ndiaye Fatou K, Ortalli Ana, Canouil Mickaël, Huyvaert Marlène, Salazar-Cardozo Clara, Lecoeur Cécile, Verbanck Marie, Pawlowski Valérie, Boutry Raphaël, Durand Emmanuelle, Rabearivelo Iandry, Sand Olivier, Marselli Lorella, Kerr-Conte Julie, Chandra Vikash, Scharfmann Raphaël, Poulain-Godefroy Odile, Marchetti Piero, Pattou François, Abderrahmani Amar, Froguel Philippe, Bonnefond Amélie

Abstract excerpt

OBJECTIVES: Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and for the development of novel treatments have been disappointing, due to poor knowledge of how these loci impact T2D pathophysiology. Here, we aimed to measure the expression of genes located nearby T2D associated...

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Identifiers

PMID: 28580277
DOI: 10.1016/j.molmet.2017.03.011
PMCID: PMC5444093

Genes

PRC1
SRR
ZFAND3
ZFAND6
GCK
KCNK16
TCF19

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