Article
High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes.
American journal of human genetics - 3 Aug 2023
Duan Yuan-Yuan, Chen Xiao-Feng, Zhu Ren-Jie, Jia Ying-Ying, Huang Xiao-Ting, Zhang Meng, Yang Ning, Dong Shan-Shan, Zeng Mengqi, Feng Zhihui, Zhu Dong-Li, Wu Hao, Jiang Feng, Shi Wei, Hu Wei-Xin, Ke Xin, Chen Hao, Liu Yunlong, Jing Rui-Hua, Guo Yan, Li Meng, Yang Tie-Lin
Abstract excerpt
Most of the single-nucleotide polymorphisms (SNPs) associated with insulin resistance (IR)-relevant phenotypes by genome-wide association studies (GWASs) are located in noncoding regions, complicating their functional interpretation. Here, we utilized an adapted STARR-seq to evaluate the regulatory activities of 5,987 noncoding SNPs associated with IR-relevant phenotypes. We identified 876 SNPs with biased...
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