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Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells

2022-09-19

Abstract excerpt

<h4>Summary</h4> Resolving causal genes for type 2 diabetes at loci implicated by genome-wide association studies (GWAS) requires integrating functional genomic data from relevant cell types. Chromatin features in endocrine cells of the pancreatic islet are particularly informative and recent studies leveraging chromosome conformation capture (3C) with Hi-C based methods have elucidated regulatory mechanisms in h...

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Literature Corpus work
6d1f3f3d-63ef-5e18-890c-8fe6fbdec1f6
DOI
10.1101/2022.09.19.508549
Open publication

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Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cellsDOI 10.1101/2022.09.19.508549
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