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Article

A map of open chromatin in human pancreatic islets.

Nature genetics - 1 Mar 2010

Gaulton Kyle J, Nammo Takao, Pasquali Lorenzo, Simon Jeremy M, Giresi Paul G, Fogarty Marie P, Panhuis Tami M, Mieczkowski Piotr, Secchi Antonio, Bosco Domenico, Berney Thierry, Montanya Eduard, Mohlke Karen L, Lieb Jason D, Ferrer Jorge

Abstract excerpt

Tissue-specific transcriptional regulation is central to human disease. To identify regulatory DNA active in human pancreatic islets, we profiled chromatin by formaldehyde-assisted isolation of regulatory elements coupled with high-throughput sequencing (FAIRE-seq). We identified approximately 80,000 open chromatin sites. Comparison of FAIRE-seq data from islets to that from five non-islet cell lines revealed...

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Identifiers

PMID: 20118932
DOI: 10.1038/ng.530
PMCID: PMC2828505

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