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Article

Colocalization analysis of 3' UTR alternative polyadenylation quantitative trait loci reveals novel mechanisms underlying associations with lung function.

Human molecular genetics - 21 Jun 2024

Saferali Aabida, Kim Wonji, Xu Zhonghui, Chase Robert P, Cho Michael H, Laederach Alain, Castaldi Peter J, Hersh Craig P

Abstract excerpt

While many disease-associated single nucleotide polymorphisms (SNPs) are expression quantitative trait loci (eQTLs), a large proportion of genome-wide association study (GWAS) variants are of unknown function. Alternative polyadenylation (APA) plays an important role in posttranscriptional regulation by allowing genes to shorten or extend 3' untranslated regions (UTRs). We hypothesized that genetic variants that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Pulmonary Disease, Chronic Obstructive

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Source

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Identifiers

PMID: 38569558
DOI: 10.1093/hmg/ddae055
PMCID: PMC12099291

Genes

BTN3A2
MARCHF2
NECTIN2

Provenance

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