Integrating apaQTL and eQTL analysis identifies a potential causal variant associated with lung adenocarcinoma risk in the Chinese population.

doi:10.1038/s42003-024-06502-0

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Integrating apaQTL and eQTL analysis identifies a potential causal variant associated with lung adenocarcinoma risk in the Chinese population.

Communications biology - 13 Jul 2024

Xu Huiwen, Wu Yutong, Chen Qiong, Yu Yuhui, Meng Qianyao, Qin Na, Zhang Wendi, Tao Xiaobo, Li Siqi, Tian Tian, Zhang Lei, Ma Hongxia, Cui Jiahua, Chu Minjie

Abstract excerpt

Alternative polyadenylation (APA) plays a crucial role in cancer biology. Here, we used data from the 3'aQTL-atlas, GTEx, and the China Nanjing Lung Cancer GWAS database to explore the association between apaQTL/eQTL-SNPs and the risk of lung adenocarcinoma (LUAD). The variant T allele of rs277646 in NIT2 is associated with an increased risk of LUAD (OR = 1.12, P = 0.015), lower PDUI values, and higher NIT2...

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PMID: 39003419
DOI: 10.1038/s42003-024-06502-0
PMCID: PMC11246497

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