Article
Texture-based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population.
Human brain mapping - 1 Aug 2024
Dounavi Maria-Eleni, Mak Elijah, Operto Gregory, Muniz-Terrera Graciela, Bridgeman Katie, Koychev Ivan, Malhotra Paresh, Naci Lorina, Lawlor Brian, Su Li, Falcon Carles, Ritchie Karen, Ritchie Craig W, Gispert Juan Domingo, O'Brien John T
Abstract excerpt
Brain atrophy and cortical thinning are typically observed in people with Alzheimer's disease (AD) and, to a lesser extent, in those with mild cognitive impairment. In asymptomatic middle-aged apolipoprotein ε4 (ΑPOE4) carriers, who are at higher risk of future AD, study reports are discordant with limited evidence of brain structural differences between carriers and non-carriers of the ε4 allele. Alternative...
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