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Article

Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2018

Cacciaglia Raffaele, Molinuevo José Luis, Falcón Carles, Brugulat-Serrat Anna, Sánchez-Benavides Gonzalo, Gramunt Nina, Esteller Manel, Morán Sebastián, Minguillón Carolina, Fauria Karine, Gispert Juan Domingo

Abstract excerpt

INTRODUCTION: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains unclear. METHODS: We analyzed gray matter volumes (GMvs) in a sample of 533 healthy middle-aged individuals with a substantial representation of ε4-carriers (207 heterozygotes and 65 homozygotes). RESULTS: We found...

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Identifiers

PMID: 29605385
DOI: 10.1016/j.jalz.2018.01.016

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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