Apolipoprotein E homozygous ε4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample.

doi:10.1016/j.euroneuro.2021.02.006

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Article

Apolipoprotein E homozygous ε4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 May 2021

Goltermann Janik, Repple Jonathan, Redlich Ronny, Dohm Katharina, Flint Claas, Grotegerd Dominik, Waltemate Lena, Lemke Hannah, Fingas Stella Mercedes, Meinert Susanne, Enneking Verena, Hahn Tim, Bauer Jochen, Schmitt Simon, Meller Tina, Stein Frederike, Brosch Katharina, Steinsträter Olaf, Jansen Andreas, Krug Axel, Nenadić Igor, Baune Bernhard T, Rietschel Marcella, Witt Stephanie, Forstner Andreas J, Nöthen Markus, Johnen Andreas, Alferink Judith, Kircher Tilo, Dannlowski Udo, Opel Nils

Abstract excerpt

Apolipoprotein E (APOE) genotype is the strongest single gene predictor of Alzheimer's disease (AD) and has been frequently associated with AD-related brain structural alterations before the onset of dementia. While previous research has primarily focused on hippocampal morphometry in relation to APOE, sporadic recent findings have questioned the specificity of the hippocampus and instead suggested more global...

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PMID: 33648793
DOI: 10.1016/j.euroneuro.2021.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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