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Article

Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Lu Po H, Thompson Paul M, Leow Alex, Lee Grace J, Lee Agatha, Yanovsky Igor, Parikshak Neelroop, Khoo Theresa, Wu Stephanie, Geschwind Daniel, Bartzokis George

Abstract excerpt

Apolipoprotein E (ApoE) ε4 genotype is a strong risk factor for developing Alzheimer's disease (AD). Conversely, the presence of the ε2 allele has been shown to mitigate cognitive decline. Tensor-based morphometry (TBM), a novel computational approach for visualizing longitudinal progression of brain atrophy, was used to determine whether cognitively intact elderly participants with the ε4 allele demonstrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21098974
DOI: 10.3233/JAD-2010-101398
PMCID: PMC3107252

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