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Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects

1 Jan 2019

Abstract excerpt

The apolipoprotein E gene (APOE) ε4 allele has a strong and manifold impact on cognition and neuroimaging phenotypes in cognitively normal subjects, including alterations in the white matter (WM) microstructure. Such alterations have often been regarded as a reflection of potential thinning of the myelin sheath along axons, rather than pure axonal degeneration. Considering the main role of APOE in brain lipid...

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PMID: 31520917
DOI: 10.1016/j.nicl.2019.101983

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