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Article

A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank.

Translational psychiatry - 12 Mar 2024

Heise Verena, Offer Alison, Whiteley William, Mackay Clare E, Armitage Jane M, Parish Sarah

Abstract excerpt

Alzheimer's disease (AD) risk is increased in carriers of the apolipoprotein E (APOE) ε4 allele and decreased in ε2 allele carriers compared with the ε3ε3 genotype. The aim of this study was to determine whether: the APOE genotype affects brain grey (GM) or white matter (WM) structure; and if differences exist, the age when they become apparent and whether there are differential effects by sex. We used...

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Identifiers

PMID: 38472178
DOI: 10.1038/s41398-024-02848-5
PMCID: PMC10933274

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