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Article

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

1 Jan 2019

Abstract excerpt

The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. However, its impact on cognitive performance is less evident. Here, we examine the impact of APOE-ε4 allele load in modulating the association between cognitive functioning and brain morphology...

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Alzheimer's disease research and treatments
Dementia and Cognitive Impairment Research
Functional Brain Connectivity Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30991302
DOI: 10.1016/j.nicl.2019.101818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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