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Article

The human mitochondrial mRNA structurome reveals mechanisms of gene expression.

Science (New York, N.Y.) - 19 Jul 2024

Moran J Conor, Brivanlou Amir, Brischigliaro Michele, Fontanesi Flavia, Rouskin Silvi, Barrientos Antoni

Abstract excerpt

The human mitochondrial genome encodes crucial oxidative phosphorylation system proteins, pivotal for aerobic energy transduction. They are translated from nine monocistronic and two bicistronic transcripts whose native structures remain unexplored, posing a gap in understanding mitochondrial gene expression. In this work, we devised the mitochondrial dimethyl sulfate mutational profiling with sequencing...

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Identifiers

PMID: 39024447
DOI: 10.1126/science.adm9238
PMCID: PMC11510358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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