Article

Cooperative Architecture of Mitochondrial Proteome Homeostasis

2026-02-09

Abstract excerpt

<h4>SUMMARY</h4> Mitochondria are semi-autonomous organelles whose generation and maintenance demand precise expression, processing, and assembly of >1,000 proteins encoded across two genomes. To explore this cooperativity, we performed multiomic analyses on >200 cell lines harboring mitochondrial gene perturbations, generating >26M molecular measurements. Our data reveal that mitochondrial proteome homeostasis i...

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Literature Corpus work: b832cc8b-ace7-54ab-a927-feb3cca5da7e
DOI: 10.64898/2026.02.06.26345691

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